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KMID : 0857020110260020149
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Kosin Medical Journal
2011 Volume.26 No. 2 p.149 ~ p.154
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High Sensitivity CRP Fibrinogen and Homocysteine in Relation to Carotid Intima-media Thickness in Acute Ischemic Stroke
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Lee Won-Gu
Kim Kwang-Soo
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Abstract
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Objective: To evaluate the relationship of high sensitivity C-reactive protein (hs-CRP), fibrinogen and homocysteine to carotid intima-media thickness (IMT) in acute ischemic stroke. Methods: Subjects were 347 patients with acute cerebral infarction. The carotid arterial wall thickness was measured using high resolution B-mode ultrasound. The serum levels of hs-CRP, fibrinogen and homocysteine were measured by latex-enhanced turbidimetric immunoassay, clot scattering method, and chemiluminescence immunoassay respectively. Univariate regression analysis was performed to evaluate the relationship between these levels and carotid IMT. Results :In patients with acute ischemic stroke, carotid IMT was significantly correlated with increased serum levels of hs-CRP and fibrinogen (P < 0.05, P < 0.01, respectively). However association between serum homocysteine and carotid IMT was not statistically significant. Conclusions: Increased serum levels of hs-CRP and fibrinogen may be correlated with carotid IMT. Measurement of serum hs-CRP and fibrinogen may be helpful for predicting degrees of atherosclerosis in acute ischemic stroke.
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KEYWORD
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Acute ischemic stroke, Carotid intima-media thickness, Fibrinogen, High sensitivity C-reactive protein, Homocysteine
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